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INSTABILITY OF FOXP3 EXPRESSION LIMITS THE ABILITY OF INDUCED REGULATORY T CELLS TO MITIGATE GRAFT VERSUS HOST DISEASE

PURPOSE: Graft versus host disease is the major complication of allogeneic bone marrow transplantation and limits the therapeutic efficacy of this modality. While the role of natural regulatory T cells (nTregs) in attenuating GVHD has been extensively examined, the ability of induced regulatory T ce...

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Detalhes bibliográficos
Main Authors: Beres, Amy, Komorowski, Richard, Mihara, Masahiko, Drobyski, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117905/
https://ncbi.nlm.nih.gov/pubmed/21558402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-3347
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