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Persistent Inactivation of Macrophage Cyclooxygenase-2 in Mycobacterial Pulmonary Inflammation
The induction of cyclooxygenase-2 (COX-2) in tissue macrophages (M∅) increases prostaglandin E(2) (PGE(2)) release, potentially down-regulating granulomatous inflammation. In response to Mycobacteria, local M∅ express COX-2, which is either nuclear envelope (NE)-associated or NE-dissociated. Persist...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Thoracic Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715904/ https://ncbi.nlm.nih.gov/pubmed/19097981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0230OC |
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