Depletion of cellular cholesterol enhances macrophage MAPK activation by chitin microparticles but not by heat-killed Mycobacterium bovis BCG

When macrophages phagocytose chitin (N-acetyl-d-glucosamine polymer) microparticles, mitogen-activated protein kinases (MAPK) are immediately activated, followed by the release of Th1 cytokines, but not IL-10. To determine whether phagocytosis and macrophage activation in response to chitin micropar...

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Auteurs principaux: Nishiyama, Akihito, Shinohara, Tsutomu, Pantuso, Traci, Tsuji, Shoutaro, Yamashita, Makiko, Shinohara, Shizuka, Myrvik, Quentin N., Henriksen, Ruth Ann, Shibata, Yoshimi
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2008
Sujets:
Protein and Vesicle Trafficking, Cytoskeleton
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518411/
https://ncbi.nlm.nih.gov/pubmed/18524942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00446.2007
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