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Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation
The relationship between formation of active in-line attack conformations and monovalent (Na(+)) and divalent (Mg(2+)) metal ion binding in the hammerhead ribozyme has been explored with molecular dynamics simulations. To stabilize repulsions between negatively charged groups, different requirements...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715853/ https://ncbi.nlm.nih.gov/pubmed/19265710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.02.054 |
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