Pharmacokinetics and Pharmacodynamics of a Novel Triazole, Isavuconazole: Mathematical Modeling, Importance of Tissue Concentrations, and Impact of Immune Status on Antifungal Effect

Isavuconazole is a triazole with broad-spectrum activity against medically important fungal pathogens. We investigated the pharmacokinetics and pharmacodynamics of isavuconazole in a murine model of disseminated candidiasis. We determined the pharmacokinetics in both plasma and kidney. The relations...

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Main Authors: Warn, Peter A., Sharp, Andrew, Parmar, Arvind, Majithiya, Jayesh, Denning, David W., Hope, William W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715589/
https://ncbi.nlm.nih.gov/pubmed/19451288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01601-08
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