Self-antigen–specific CD8(+) T cell precursor frequency determines the quality of the antitumor immune response

A primary goal of cancer immunotherapy is to improve the naturally occurring, but weak, immune response to tumors. Ineffective responses to cancer vaccines may be caused, in part, by low numbers of self-reactive lymphocytes surviving negative selection. Here, we estimated the frequency of CD8(+) T c...

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Bibliografski detalji
Glavni autori: Rizzuto, Gabrielle A., Merghoub, Taha, Hirschhorn-Cymerman, Daniel, Liu, Cailian, Lesokhin, Alexander M., Sahawneh, Diana, Zhong, Hong, Panageas, Katherine S., Perales, Miguel-Angel, Altan-Bonnet, Grégoire, Wolchok, Jedd D., Houghton, Alan N.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715122/
https://ncbi.nlm.nih.gov/pubmed/19332877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081382
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