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Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
In rheumatoid arthritis (RA), dysfunctional T cells sustain chronic inflammatory immune responses in the synovium. Even unprimed T cells are under excessive replication pressure, suggesting an intrinsic defect in T cell regeneration. In naive CD4 CD45RA(+) T cells from RA patients, DNA damage load a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715066/ https://ncbi.nlm.nih.gov/pubmed/19451263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082251 |
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