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The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription
The activation-induced cytidine deaminase (AID) initiates somatic hypermutation, class-switch recombination, and gene conversion of immunoglobulin genes. In vitro, AID has been shown to target single-stranded DNA, relaxed double-stranded DNA, when transcribed, or supercoiled DNA. To simulate the in...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715043/ https://ncbi.nlm.nih.gov/pubmed/19380635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082678 |
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