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DnaAcos Hyperinitiates by Circumventing Regulatory Pathways that Control the Frequency of Initiation in Escherichia coli
Mutants of dnaAcos are inviable at 30°C because DnaAcos hyperinitiates, leading to new replication forks that apparently collide from behind with stalled forks, thereby generating lethal double strand breaks. By comparison, an elevated level of DnaA also induces extra initiations, but lethality occu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714686/ https://ncbi.nlm.nih.gov/pubmed/19432804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2009.06724.x |
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