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Antigen-presenting cells containing multiple costimulatory molecules promote activation and expansion of antigen-specific memory CD8(+) T cells

We have previously demonstrated that multiple immunizations with vector-based vaccines containing transgenes for tumor Ags and a triad of costimulatory molecules (TRICOM) enhance the expansion and functional avidity of Ag-specific memory CD8(+) T cells in a mouse model. However, the effect of enhanc...

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Detalhes bibliográficos
Main Authors: Yang, Sixun, Schlom, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714549/
https://ncbi.nlm.nih.gov/pubmed/18690438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0572-8
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