Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

BACKGROUND: Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Cheung, Chun Hei Antonio, Chen, Huang-Hui, Kuo, Ching-Chuan, Chang, Chi-Yen, Coumar, Mohane S, Hsieh, Hsing-Pang, Chang, Jang-Yang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2009
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714493/
https://ncbi.nlm.nih.gov/pubmed/19575780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-43
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