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Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers
BACKGROUND: Survivin is a dual function protein. It inhibits the apoptosis of cells by inhibiting caspases, and also promotes cell growth by stabilizing microtubules during mitosis. Over-expression of survivin has been demonstrated to induce drug-resistance to various chemo-therapeutic agents such a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714493/ https://ncbi.nlm.nih.gov/pubmed/19575780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-8-43 |
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