The molecular basis of hepcidin-resistant hereditary hemochromatosis

The interaction between the hormone hepcidin and the iron exporter ferroportin (Fpn) regulates plasma iron concentrations. Hepcidin binds to Fpn and induces its internalization and degradation, resulting in decreased iron efflux from cells into plasma. Fpn mutations in N144, Y64N, and C326 residue c...

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Bibliografiske detaljer
Main Authors: Fernandes, Augustine, Preza, Gloria C., Phung, Yen, De Domenico, Ivana, Kaplan, Jerry, Ganz, Tomas, Nemeth, Elizabeta
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714214/
https://ncbi.nlm.nih.gov/pubmed/19383972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-146134
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