The molecular basis of hepcidin-resistant hereditary hemochromatosis

The interaction between the hormone hepcidin and the iron exporter ferroportin (Fpn) regulates plasma iron concentrations. Hepcidin binds to Fpn and induces its internalization and degradation, resulting in decreased iron efflux from cells into plasma. Fpn mutations in N144, Y64N, and C326 residue c...

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Detalhes bibliográficos
Main Authors: Fernandes, Augustine, Preza, Gloria C., Phung, Yen, De Domenico, Ivana, Kaplan, Jerry, Ganz, Tomas, Nemeth, Elizabeta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714214/
https://ncbi.nlm.nih.gov/pubmed/19383972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-146134
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