The molecular basis of hepcidin-resistant hereditary hemochromatosis

The interaction between the hormone hepcidin and the iron exporter ferroportin (Fpn) regulates plasma iron concentrations. Hepcidin binds to Fpn and induces its internalization and degradation, resulting in decreased iron efflux from cells into plasma. Fpn mutations in N144, Y64N, and C326 residue c...

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Detaylı Bibliyografya
Asıl Yazarlar: Fernandes, Augustine, Preza, Gloria C., Phung, Yen, De Domenico, Ivana, Kaplan, Jerry, Ganz, Tomas, Nemeth, Elizabeta
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2009
Konular:
Red Cells, Iron, and Erythropoiesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714214/
https://ncbi.nlm.nih.gov/pubmed/19383972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-146134
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