IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

Murine models indicate that interleukin-10 (IL-10) can suppress viral clearance, and interventional blockade of IL-10 activity has been proposed to enhance immunity in chronic viral infections. Increased IL-10 levels have been observed during HIV infection and IL-10 blockade has been shown to enhanc...

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Main Authors: Brockman, Mark A., Kwon, Douglas S., Tighe, Daniel P., Pavlik, David F., Rosato, Pamela C., Sela, Jennifer, Porichis, Filippos, Le Gall, Sylvie, Waring, Michael T., Moss, Kristin, Jessen, Heiko, Pereyra, Florencia, Kavanagh, Daniel G., Walker, Bruce D., Kaufmann, Daniel E.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2009
主題:
Immunobiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714209/
https://ncbi.nlm.nih.gov/pubmed/19365081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-191296
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