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Deciphering the Code to Aminergic G-Protein Coupled Receptor Drug Design

The trace amine-associated receptor 1 (TAAR(1)) is a biogenic amine G-protein coupled receptor (GPCR) that is potently activated by 3-iodothyronamine (1, T(1)AM) in vitro. Compound 1 is an endogenous derivative of the thyroid hormone thyroxine that rapidly induces hypothermia, anergia, and bradycard...

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Bibliografiske detaljer
Main Authors: Tan, Edwin S., Groban, Eli S., Jacobson, Matthew P., Scanlan, Thomas S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713717/
https://ncbi.nlm.nih.gov/pubmed/18420141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.03.004
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