Role of SUMO in RNF4-mediated Promyelocytic Leukemia Protein (PML) Degradation: Sumoylation of pml and phospho-switch control of its sumo binding domain dissected in living cells([Image: see text])

Promyelocytic leukemia protein (PML) is a tumor suppressor acting as the organizer of subnuclear structures called PML nuclear bodies (NBs). Both covalent modification of PML by the small ubiquitin-like modifier (SUMO) and non-covalent binding of SUMO to the PML SUMO binding domain (SBD) are necessa...

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Bibliographische Detailangaben
Hauptverfasser: Percherancier, Yann, Germain-Desprez, Delphine, Galisson, Frédéric, Mascle, Xavier H., Dianoux, Laurent, Estephan, Patricia, Chelbi-Alix, Mounira K., Aubry, Muriel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713554/
https://ncbi.nlm.nih.gov/pubmed/19380586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006387
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