Anterograde Transport of Surfactant Protein C Proprotein to Distal Processing Compartments Requires PPDY-mediated Association with Nedd4 Ubiquitin Ligases

Biosynthesis of surfactant protein C (SP-C) by alveolar type 2 cells requires proteolytic processing of a 21-kDa propeptide (proSP-C(21)) in post-Golgi compartments to yield a 3.7-kDa mature form. Scanning alanine mutagenesis, binding assays, and co-immunoprecipitation were used to characterize the...

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Detalhes bibliográficos
Main Authors: Kotorashvili, Adam, Russo, Scott J., Mulugeta, Surafel, Guttentag, Susan, Beers, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713532/
https://ncbi.nlm.nih.gov/pubmed/19366705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002816
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