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Nucleophosmin Blocks Mitochondrial Localization of p53 and Apoptosis
Activation of p53 is an important mechanism in apoptosis. However, whether the presence of p53 in mitochondria plays an important role in p53-mediated apoptosis is unclear. Here, we demonstrate that overexpression of NPM (nucleophosmin) significantly suppresses 12-O-tetradecanoylphorbol 13-acetate (...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713525/ https://ncbi.nlm.nih.gov/pubmed/19366707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005736 |
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