Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

The MLL-ELL fusion gene results from the translocation t(11;19)(q23;p13.1) that is associated with de novo and therapy-related acute myeloid leukemia. To study its transforming properties, we retrovirally transduced primary murine hematopoietic progenitors and assessed their growth properties both i...

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Bibliographic Details
Main Authors: Lavau, Catherine, Luo, Roger T., Du, Changchun, Thirman, Michael J.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC27135/
https://ncbi.nlm.nih.gov/pubmed/10995463
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