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Functional Analysis of Phenylalanine Residues in the Active Site of CYP2C9
The two published crystal structures of CYP2C9, complexed with (S)-warfarin or flurbiprofen, implicate a cluster of three active-site phenylalanine residues (F100, F114, F476) in ligand binding. However, these three residues appear to interact differently with these two ligands based on the static c...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713172/ https://ncbi.nlm.nih.gov/pubmed/18922023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801231m |
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