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Substrate Proton to Heme Distances in CYP2C9 Allelic Variants and Alterations by the Heterotropic Activator, Dapsone
CYP2C9 polymorphisms result in reduced enzyme catalytic activity and greater activation by effector molecules as compared to wild type protein, with the mechanism(s) for these changes in activity not fully elucidated. Through T(1) NMR and spectral binding analyses, mechanism(s) for these differences...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2467441/ https://ncbi.nlm.nih.gov/pubmed/18485885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.04.034 |
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