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Conformational changes in a pore-forming region underlie voltage-dependent “loop gating” of an unapposed connexin hemichannel

The structure of the pore is critical to understanding the molecular mechanisms underlying selective permeation and voltage-dependent gating of channels formed by the connexin gene family. Here, we describe a portion of the pore structure of unapposed hemichannels formed by a Cx32 chimera, Cx32*Cx43...

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Bibliografiske detaljer
Main Authors: Tang, Qingxiu, Dowd, Terry L., Verselis, Vytas K., Bargiello, Thaddeus A.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713147/
https://ncbi.nlm.nih.gov/pubmed/19468074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910207
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