Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms

We examined the interaction between the multikinase inhibitor sorafenib and histone deacetylase inhibitors. Sorafenib and vorinostat synergized (sorafenib + vorinostat) to kill HCT116 and SW480 cells. In SW480 cells, sorafenib + vorinostat increased CD95 plasma membrane levels and promoted death-ind...

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Detalhes bibliográficos
Main Authors: Walker, Teneille, Mitchell, Clint, Park, Margaret A., Yacoub, Adly, Graf, Martin, Rahmani, Mohamed, Houghton, Peter J., Voelkel-Johnson, Christina, Grant, Steven, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713126/
https://ncbi.nlm.nih.gov/pubmed/19483104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056523
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