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Hyper-costimulation Through 4-1BB Distorts Homeostasis of Immune cells
The deleterious side-effects associated with a recent clinical trial with anti-CD28 super-agonist antibodies have questioned the use of reagents to costimulatory molecules in human therapy. We now show that sustained signaling from an agonist antibody to 4-1BB, a member of the tumor necrosis factor...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713069/ https://ncbi.nlm.nih.gov/pubmed/19454670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803241 |
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