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Ionic selectivity in L-type calcium channels by electrostatics and hard-core repulsion

A physical model of selective “ion binding” in the L-type calcium channel is constructed, and consequences of the model are compared with experimental data. This reduced model treats only ions and the carboxylate oxygens of the EEEE locus explicitly and restricts interactions to hard-core repulsion...

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Hlavní autoři: Boda, Dezső, Valiskó, Mónika, Henderson, Douglas, Eisenberg, Bob, Gillespie, Dirk, Nonner, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712969/
https://ncbi.nlm.nih.gov/pubmed/19398776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910211
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