A conditional transposon-based insertional mutagenesis screen for hepatocellular carcinoma-associated genes in mice

Here we describe a Sleeping Beauty (SB) transposition system that utilizes a conditional SB transposase allele, which can be activated by Cre recombinase to drive the transposition of a mutagenic transposon in virtually any tissue and control the type of cancer produced. To demonstrate the potential...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Keng, Vincent W., Villanueva, Augusto, Chiang, Derek Y., Dupuy, Adam J., Ryan, Barbara J., Matise, Ilze, Silverstein, Kevin A.T., Sarver, Aaron, Starr, Timothy K., Akagi, Keiko, Tessarollo, Lino, Collier, Lara S., Powers, Scott, Lowe, Scott W., Jenkins, Nancy A., Copeland, Neal G., Llovet, Josep M., Largaespada, David A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712727/
https://ncbi.nlm.nih.gov/pubmed/19234449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1526
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