Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

BACKGROUND: Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully chemoresistant, fatal disease. Although the precise mechan...

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Detalhes bibliográficos
Main Authors: Li, Meng, Balch, Curt, Montgomery, John S, Jeong, Mikyoung, Chung, Jae Hoon, Yan, Pearlly, Huang, Tim HM, Kim, Sun, Nephew, Kenneth P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712480/
https://ncbi.nlm.nih.gov/pubmed/19505326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-2-34
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