G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor

Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Gα(13) signal destabilizes AhR by promoting the ubiquitination of AhR. Gα(13) intera...

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Sonraí Bibleagrafaíochta
Main Authors: Nakata, Asuka, Urano, Daisuke, Fujii-Kuriyama, Yoshiaki, Mizuno, Norikazu, Tago, Kenji, Itoh, Hiroshi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2009
Ábhair:
Scientific Report
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711834/
https://ncbi.nlm.nih.gov/pubmed/19390533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.35
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