Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

Although an immunoregulatory role of aryl hydrocarbon receptor (Ahr) has been demonstrated in T cells and macrophages, little is known about its function in dendritic cells (DC). Here, we show that lipopolysaccharide (LPS) and CpG stimulate Ahr expression in bone marrow-derived dendritic cells (BMDC...

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Autors principals: Nguyen, Nam Trung, Kimura, Akihiro, Nakahama, Taisuke, Chinen, Ichino, Masuda, Kazuya, Nohara, Keiko, Fujii-Kuriyama, Yoshiaki, Kishimoto, Tadamitsu
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993339/
https://ncbi.nlm.nih.gov/pubmed/21041655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014465107
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