G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor

Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Gα(13) signal destabilizes AhR by promoting the ubiquitination of AhR. Gα(13) intera...

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Detalhes bibliográficos
Main Authors: Nakata, Asuka, Urano, Daisuke, Fujii-Kuriyama, Yoshiaki, Mizuno, Norikazu, Tago, Kenji, Itoh, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Scientific Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711834/
https://ncbi.nlm.nih.gov/pubmed/19390533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.35
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