G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor

Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Gα(13) signal destabilizes AhR by promoting the ubiquitination of AhR. Gα(13) intera...

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Библиографические подробности
Главные авторы: Nakata, Asuka, Urano, Daisuke, Fujii-Kuriyama, Yoshiaki, Mizuno, Norikazu, Tago, Kenji, Itoh, Hiroshi
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2009
Предметы:
Scientific Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711834/
https://ncbi.nlm.nih.gov/pubmed/19390533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.35
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