G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor

Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Gα(13) signal destabilizes AhR by promoting the ubiquitination of AhR. Gα(13) intera...

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Dettagli Bibliografici
Autori principali: Nakata, Asuka, Urano, Daisuke, Fujii-Kuriyama, Yoshiaki, Mizuno, Norikazu, Tago, Kenji, Itoh, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
Soggetti:
Scientific Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711834/
https://ncbi.nlm.nih.gov/pubmed/19390533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.35
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