G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor

Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Gα(13) signal destabilizes AhR by promoting the ubiquitination of AhR. Gα(13) intera...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Nakata, Asuka, Urano, Daisuke, Fujii-Kuriyama, Yoshiaki, Mizuno, Norikazu, Tago, Kenji, Itoh, Hiroshi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
Sujets:
Scientific Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711834/
https://ncbi.nlm.nih.gov/pubmed/19390533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.35
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