Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene family underlie the MMP, a landmark for hereditary nonpolyposis colorectal cancer. These tumors define a distinctive pa...

Full description

Saved in:
Bibliographic Details
Main Authors: Ionov, Yurij, Yamamoto, Hiroyuki, Krajewski, Stanislaw, Reed, John C., Perucho, Manuel
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC27116/
https://ncbi.nlm.nih.gov/pubmed/10984511
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items