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Towards the stereoselective synthesis of α-methylated (2S,3aS,7aS)-octahydroindole-2-carboxylic acid

A high yielding and remarkably stereoselective α-methylation reaction of the (2S,3aS,7aS) stereoisomer of octahydroindole-2-carboxylic acid, (S,S,S)-Oic, suitably protected is described. The severe steric hindrance imposed by the fused cyclohexane ring, which prevents the application of Seebach’s se...

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Detalhes bibliográficos
Main Authors: Sayago, Francisco J., Calaza, M. Isabel, Jiménez, Ana I., Cativiela, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711560/
https://ncbi.nlm.nih.gov/pubmed/20011581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetasy.2008.11.030
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