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Repair Kinetics of trans-4-Hydroxynonenal-Induced Cyclic 1,N(2)-Propanodeoxyguanine DNA Adducts by Human Cell Nuclear Extracts
trans-4-Hydroxynonenal (HNE) is a major peroxidation product of ω-6 polyunsaturated fatty acids. The reaction of HNE with DNA produces four diastereomeric 1,N(2)-γ-hydroxypropano adducts of deoxyguanosine (HNE-dG); background levels of these adducts have been detected in tissues of animals and human...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711554/ https://ncbi.nlm.nih.gov/pubmed/15182193 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi049877r |
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