Repair Kinetics of trans-4-Hydroxynonenal-Induced Cyclic 1,N(2)-Propanodeoxyguanine DNA Adducts by Human Cell Nuclear Extracts

trans-4-Hydroxynonenal (HNE) is a major peroxidation product of ω-6 polyunsaturated fatty acids. The reaction of HNE with DNA produces four diastereomeric 1,N(2)-γ-hydroxypropano adducts of deoxyguanosine (HNE-dG); background levels of these adducts have been detected in tissues of animals and human...

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Hlavní autoři: Choudhury, Sujata, Pan, Jishen, Amin, Shantu, Chung, Fung-Lung, Roy, Rabindra
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711554/
https://ncbi.nlm.nih.gov/pubmed/15182193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi049877r
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