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Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens
In the phase IIb STEP trial an HIV-1 vaccine based on adenovirus (Ad) vectors of the human serotype 5 (AdHu5) not only failed to induce protection but also increased susceptibility to HIV-1 infection in individuals with pre-existing neutralizing antibodies against AdHu5. The mechanisms underlying th...
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Main Authors: | , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711537/ https://ncbi.nlm.nih.gov/pubmed/19414814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900317 |
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