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Force Field Bias in Protein Folding Simulations

Long timescale (>1 μs) molecular dynamics simulations of protein folding offer a powerful tool for understanding the atomic-scale interactions that determine a protein's folding pathway and stabilize its native state. Unfortunately, when the simulated protein fails to fold, it is often uncle...

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Detalhes bibliográficos
Main Authors: Freddolino, Peter L., Park, Sanghyun, Roux, Benoît, Schulten, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711430/
https://ncbi.nlm.nih.gov/pubmed/19413983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.033
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