Intrinsic Dynamics of Restriction Endonuclease EcoO109I Studied by Molecular Dynamics Simulations and X-Ray Scattering Data Analysis

EcoO109I is a type II restriction endonuclease that functions as a dimer in solution. Upon DNA binding to the enzyme, the two subunits rotate counterclockwise relative to each other, as the two catalytic domains undergo structural changes to capture the cognate DNA. Using a 150-ns molecular dynamics...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Oroguchi, Tomotaka, Hashimoto, Hiroshi, Shimizu, Toshiyuki, Sato, Mamoru, Ikeguchi, Mitsunori
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2009
Témata:
Protein
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711268/
https://ncbi.nlm.nih.gov/pubmed/19348764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.12.3914
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky