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Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf
Mice lacking p63 cannot form skin, exhibit craniofacial and skeletal defects, and die soon after birth. The p63 gene regulates a complex network of target genes, and disruption of p63 has been shown to affect the maintenance of epithelial stem cells, the differentiation of keratinocytes, and the pre...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711186/ https://ncbi.nlm.nih.gov/pubmed/19494829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.151 |
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