Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

High Temperature Requirement A2 (HtrA2/Omi) is a mitochondrial protease that exhibits pro-apoptotic and cell protective properties and has been linked to Parkinson disease (PD). Impaired mitochondrial function is a common trait in PD patients, and is likely to play a significant role in pathogenesis...

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Bibliografiska uppgifter
Huvudupphovsmän: Tain, Luke S., Chowdhury, Ruhena B., Tao, Ran N., Plun-Favreau, Helene, Moisoi, Nicoleta, Martins, L. Miguel, Downward, Julian, Whitworth, Alexander J., Tapon, Nicolas
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711053/
https://ncbi.nlm.nih.gov/pubmed/19282869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.23
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