PUMA and Bax-induced Autophagy Contributes to Apoptosis

The p53-inducible BH3-only protein PUMA is a key mediator of p53-dependent apoptosis, and PUMA has been shown to function by activating Bax and mitochondrial outer membrane permeabilization. In this study we describe an ability of PUMA to induce autophagy that leads to the selective removal of mitoc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yee, Karen S., Wilkinson, Simon, James, John, Ryan, Kevin M., Vousden, Karen H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711052/
https://ncbi.nlm.nih.gov/pubmed/19300452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2009.28
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge