MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1

Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding RNAs that regulate gene expression by targeting protein-coding mRNAs. Recently, miRNAs have been shown to play a role as both targets...

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Main Authors: Garzon, Ramiro, Liu, Shujun, Fabbri, Muller, Liu, Zhongfa, Heaphy, Catherine E.A., Callegari, Elisa, Schwind, Sebastian, Pang, Jiuxia, Yu, Jianhua, Muthusamy, Natarajan, Havelange, Violaine, Volinia, Stefano, Blum, William, Rush, Laura J., Perrotti, Danilo, Andreeff, Michael, Bloomfield, Clara D., Byrd, John C., Chan, Kenneth, Wu, Lai-Chu, Croce, Carlo M., Marcucci, Guido
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2009
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710934/
https://ncbi.nlm.nih.gov/pubmed/19211935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-170589
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