Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

CD4+ T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an antigen associated with the self-limited form of the disease. Biochemical purification and genetic analysis identified the T cell antigen as a conserved mycobacterial lipogl...

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Main Authors: Sieling, Peter A., Hill, Preston J., Dobos, Karen M., Brookman, Kerry, Kuhlman, Andrew M., Fabri, Mario, Krutzik, Stephan R., Rea, Thomas H., Heaslip, Darragh G., Belisle, John T, Modlin, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710377/
https://ncbi.nlm.nih.gov/pubmed/18424702
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