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β8 integrins are required for vascular morphogenesis in mouse embryos
In order to assess the in vivo function of integrins containing the β8 subunit, we have generated integrin β8- deficient mice. Ablation of β8 results in embryonic or perinatal lethality with profound defects in vascular development. Sixty-five percent of integrin β8-deficient embryos die at midgesta...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2002
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2710098/ https://ncbi.nlm.nih.gov/pubmed/12050137 |
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