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Purinergic P2X(7) receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival
AIMS/HYPOTHESIS: In obesity, beta cells activate compensatory mechanisms to adapt to the higher insulin demand. Interleukin-1 receptor antagonist (IL-1Ra) prevents obesity-induced hyperglycaemia and is a potent target for the treatment of diabetes, but the mechanisms of its secretion and regulation...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer-Verlag
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709906/ https://ncbi.nlm.nih.gov/pubmed/19396427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-009-1349-0 |
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