ROLE OF CYTOCHROME P450 2C8 AND 2J2 GENOTYPE IN CALCINEURIN INHIBITOR INDUCED CHRONIC KIDNEY DISEASE

OBJECTIVES: The calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus (Tac) help prevent allograft rejection but are associated with nephrotoxicity. Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicos...

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Detalhes bibliográficos
Main Authors: Smith, Helen E., Jones, JP., Kalhorn, Thomas F., Farin, Fredrico M., Stapleton, Patricia L., Davis, Connie L., Perkins, James D., Blough, David K., Hebert, Mary F., Thummel, Kenneth E., Totah, Rheem A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709795/
https://ncbi.nlm.nih.gov/pubmed/18769365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32830e1e16
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