ROLE OF CYTOCHROME P450 2C8 AND 2J2 GENOTYPE IN CALCINEURIN INHIBITOR INDUCED CHRONIC KIDNEY DISEASE

OBJECTIVES: The calcineurin inhibitors (CNIs) cyclosporine A (CsA) and tacrolimus (Tac) help prevent allograft rejection but are associated with nephrotoxicity. Cytochrome P450 2C8 (CYP2C8) and CYP2J2 are polymorphic enzymes expressed in the kidney that metabolize arachidonic acid (AA) to epoxyeicos...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Smith, Helen E., Jones, JP., Kalhorn, Thomas F., Farin, Fredrico M., Stapleton, Patricia L., Davis, Connie L., Perkins, James D., Blough, David K., Hebert, Mary F., Thummel, Kenneth E., Totah, Rheem A.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709795/
https://ncbi.nlm.nih.gov/pubmed/18769365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32830e1e16
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares