Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations

We have shown that manassantin A downregulated the HIF-1α expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

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Главные авторы: Kasper, Amanda C., Moon, Eui Jung, Hu, Xiangqian, Park, Yongho, Wooten, Ceshea M., Kim, Hyoungsu, Yang, Weitao, Dewhirst, Mark W., Hong, Jiyong
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709708/
https://ncbi.nlm.nih.gov/pubmed/19423348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.04.071
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